You may have seen leucovorin (also called folinic acid) mentioned as a possible treatment for autism. Here’s what parents should know about this supplement, what it’s used for, and why experts don’t currently recommend it for most kids with autism.

What is leucovorin (folinic acid) and what is it usually used for?

Folinic acid, also called leucovorin, is a type of vitamin. Healthcare providers give it to patients who take certain cancer medicines or who have very low folate levels. Folate is a type of vitamin B.

Is leucovorin recommended for autism?

No, Leucovorin is not recommended as a regular treatment for autism. It is being studied to treat a rare condition called cerebral folate deficiency (CFD).

What does the latest information say about leucovorin and autism?

Recent public statements have brought attention to leucovorin, but no medical groups currently recommend it for treating autism. The FDA is looking to approve leucovorin for a rare condition called cerebral folate deficiency (CFD). CFD can have some symptoms like autism, but also other problems like seizures and movement issues. We do not prescribe leucovorin for autism unless your child also has CFD.

Should my child get folate receptor antibody testing (FRAT)?

Folate receptor antibody testing, or FRAT, is a type of blood test. Research shows that it does not help to diagnose or treat autism. Medical groups do not recommend FRAT testing for children with autism. Many of these tests are not proven and are not paid for by insurance. Children’s National laboratory does not offer this test because we want to protect families from extra costs and procedures.

Is leucovorin safe?

Most children in studies had mild side effects like upset stomach, trouble sleeping or feeling irritable. However, some children had more agitation or aggression. More research is needed to understand long-term safety.

Should I ask my doctor about leucovorin for my child?

Leucovorin is not usually given to children with autism unless they are in a research study or have test results showing CFD. Many children do well with supportive therapy, educational strategies and behavioral interventions. Talk to your provider about the best options for your child.

Key takeaways

Leucovorin is still being studied and we do not recommend it for autism at this time. Autism is a lifelong condition and it is our goal to support each child’s development and well-being, while respecting their unique strengths.

Children’s National is committed to providing the best care for all patients and families. If you have questions or concerns, talk to your child’s doctor about the best options for their care.

We will continue to follow the latest research and will update our care as the recommendations change.